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Year : 2021  |  Volume : 13  |  Issue : 3  |  Page : 254-257

Effect of hormonal manipulation using clomiphene citrate prior to microdissection testicular sperm retrieval

Department of Surgery, Division of Urology, Ministry of the National Guard - Health Affairs; King Abdullah International Medical Research Center; Department of Surgery, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Abdulmalik Addar
2682 Prince Muteb bin Abdulah Street, Ar Rimayah, Riyadh 14611
Saudi Arabia
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DOI: 10.4103/UA.UA_129_20

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Introduction: Microdissection Testicular Sperm Extraction (micro-TESE) is a surgical method used for retrieving sperm from men with non-obstructive azoospermia. Clomiphene citrate (CC) is a selective estrogen receptor modulator (SERM) that stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. It is believed that treating patients with CC prior to micro-TESE increases the chance of sperm retrieval. Methods: This retrospective study was conducted in a tertiary care center in Riyadh, Saudi Arabia and included all patients who underwent Micro-TESE from August 2015 to November 2018. Data related to the pre-surgery hormonal levels, testicular volume, and associated genetic abnormalities were collected. chi-square and t-test were used to compare variables. A p-value of less than 0.05 was considered significant. Results: A total of 122 patients were included in this study, with 30.0% (n=37) treated with CC. The overall sperm retrieval rate was 44.3%. Micro-TESE results were not statistically affected by age, testosterone levels, Klinefelter syndrome, or taking CC. However, higher testicular volumes and lower LH and FSH levels had more positive micro-TESE results. Conclusion: In conclusion, Micro-TESE results were not affected by CC, age or testicular volume.

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